Podoplanin: Transmembrane Glycoprotein Receptor

Regulator of Key Activities for Transformation, Progression & Tumor Cell Survival

Early Expressed Prognostic Biomarker Correlated with Poor Outcomes

Tumor Cell migration and survival

* PDPN plays a role in early tissue development but not usually expressed in normal adult tissues – Low levels can be found in alveolar lung cells, kidney podocytes and lymph vessel linings (no histological changes noted in animal studies after dosing with MASL)

The Biology Behind the Opportunity

1. Appears Early
PDPN shows up early in cancer transformation, making it relevant before the disease becomes advanced.

2. Persists Through Progression
It remains present as tumors grow and become more aggressive and harder to treat, relevant at every stage.

3. Drives Aggressive Behavior
PDPN is linked to tumor growth, migration, invasion, immune evasion, and drug resistance.

4. Correlates With Poor Outcomes
PDPN expression is associated with disease progression, recurrence risk, and poor survival rates.