How MASL Works

MASL Inhibits Motility, Proliferation and Metastasis by Blocking Podoplanin (PDPN) Signaling

One Blockade. Two Parallel Effects. Three Ways To Stop The Cancer.

How MASL works

MASL: First-in-Class Therapy Targeting Key Drivers of Cancer Invasion and Resistance

MASL Impacts Multiple Facets of Cancer Progression

  • Binds to podoplanin (PDPN), an early expressed prognostic biomarker present in multiple cancers that causes poor outcomes
  • Blocks key cancer signaling pathways
    • RAS-GTP – Impairs tumor cell growth/invasion
    • TGF-β SMAD – Impedes invasion and metastasis
    • JAK-STAT – Inhibits immune evasion/resistance and boosts host anti-tumor immune response
    • Wnt/β-catenin – Disrupts cancer cell migration/metastatic spread
  • Induces necrotic tumor cell death that alters the tumor microenvironment and stimulates host anti-tumor immunity
  • Distinct and additive mechanism from SOC treatments, enables use alone and with other therapies
MASL molecular structure model

MASL molecular structure model